Each round of the Grand Challenges Explorations initiative awards grants against a set of specific topics. In general, topics are chosen according to three major criteria:
- The topic fits within the goals and disease priorities of the Bill & Melinda Gates Foundation
- The topic contains a roadblock where radical, new thinking is needed for the discovery of an effective health solution
- Potential projects within the topic are likely to be well suited for the phased structure of the initiative
In addition, we consider whether a topic will engage the participation from scientists outside traditional global health disciplines, as well as researchers working in the developing world.