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 Grand Challenges Explorations Grants

Grand Challenges Explorations fosters creative projects that show great promise to improve the health of people in the developing world. Initial grants are awarded two times a year, and successful projects have the opportunity to receive additional funding of up to $1 million.

On May 10, 2010, the Gates Foundation announced that 78 new global health projects received Grand Challenges Explorations grants. Learn more about these below. Round 5 grants will be announced in October 2010.

To review all 340 Explorations projects, select "Show All Rounds" in the Round drop-down menu.

 Find Awarded Grants By
Topic
Technologies
Round
Showing Grants 1 to 5 of 5
Dominant Lethal Probes to Investigate Latency in TB
Primary Investigator:
Babak Javid, Harvard School of Public Health, Boston, MA, United States - US
Topic:
Explore the Basis For Latency in Tuberculosis
Round:
Round 2 – May 2009
The physiology of the tuberculosis bacteria during latency is not well understood.  Babak Javid of the Harvard School of Public Health in the U.S. will explore the hypothesis that latent bacteria are metabolically active during latency. The team will use novel genetic probes to determine whether transcription and translation occur in the population of cells that are responsible for re-activation of TB from models of latency.
Latency and Reactivation Revealed by Dynamic Imaging
Primary Investigator:
Philana Lin, University of Pittsburgh, Pittsburgh, PA, United States - US
Topic:
Explore the Basis For Latency in Tuberculosis
Round:
Round 2 – May 2009
Philana Ling Lin of the University of Pittsburgh in the U.S. will utilize imaging technologies such as PET and CT scans to study the biological mechanisms related to the reactivation of latent TB. This new technology aims to better understand the fundamental characteristics reactivation, as well as providing insight about new ways to induce or limit reactivation of latent TB. 
Latency in M. tuberculosis – A Highly Dynamic Phenomenon
Primary Investigator:
Maria Lerm, Linkoping University, Linkoping, Ostergotland, Sweden - SE
Topic:
Explore the Basis For Latency in Tuberculosis
Round:
Round 2 – May 2009
Maria Lerm of Linkoping University in Sweden will test her hypothesis that TB latency is a dynamic process in which a portion of the bacilli, when ingested by macrophages, trigger a genetic program where bacteria cycle between active and latent phases. Understanding whether this dynamic cycle exists could give new insights into maintaining or targeting the latent bacteria, which is the major reservoir of TB globally.
Metabolosomes: The Organizing Principle of Latency in Mtb
Primary Investigator:
Kyu Rhee, Weill Cornell Medical College, New York, NY, United States - US
Topic:
Explore the Basis For Latency in Tuberculosis
Round:
Round 2 – May 2009
Kyu Rhee of Weill Cornell Medical College in the U.S. will test the theory that tuberculosis utilizes metabolosomes, which are protein-based metabolic structures, to enter into, maintain, and exit from latency. Understanding how metabolosomes work will aid in development of drugs that target TB.
Stem Cell Basis of Tubercular Latency
Primary Investigator:
Bikul Das, Stanford University, Stanford, CA, United States - US
Topic:
Explore the Basis For Latency in Tuberculosis
Round:
Round 2 – May 2009

Because adult stem cells reside in a microenvironment that maintains an inactive metabolic state, Bikul Das of Stanford University in the U.S. will examine whether TB hijacks this niche to maintain latency.

 How to Apply

 Map of Grants
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