Showing Grants 1 to 9 of 9 |
| Chromatin Condensation: The Master Switch for Latency |
| | Sarah Fortune, Harvard University, Boston, MA, United States - US |
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Sarah Fortune of Harvard University will research whether chromatin crystallization, in which DNA condenses into a protective matrix due to environmental stress, occurs in tuberculosis and is a characteristic of latent organisms. |
| Granuloma Grafting: A New Model for Mycobacterial Latency and Reactivation |
| | Matyas Sandor, University of Wisconsin, Madison, WI, United States - US |
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Matyas Sandor of the University of Wisconsin will graft granulomas, nodules that form as a result of long-term inflammation , to study the role they play in TB latency and reactivation. |
| Human Genetics of Tuberculosis Infection |
| | Alexandre Alcais, Inserm, Paris, France - FR |
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Alexandre Alcais of French National Institute for Health and Medical Research will study whether there is a genetic basis for innate resistance to TB infection through genome-wide linkage analysis of TB-specific T-cell phenotypes. |
| Interruption of Latency and In Vivo Adenovirus-Mediated Elimination of Macrophages Infected with M. Tuberculosis |
| | Dmitry Shayakhmetov, University of Washington, Seattle, WA, United States - US |
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Pulmonary macrophages are the principal host of tuberculosis, where it can remain latent and inaccessible to current TB drug therapies. Dmitry Shayakhmetov of the University of Washington will study whether infecting these host cells with adenovirus will induce rapid cell death, reducing TB load and blocking the re-infection cycle. |
| Investigating the Persistence of Infection with M. Tuberculosis |
| | Amelia Crampin, London School of Hygiene & Tropical Medicine, London, United Kingdom - GB |
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Amelia Crampin of the London School of Hygiene & Tropical Medicine will study a group of people found to have latent tuberculosis in the 1980s to test her hypothesis that a measurable portion of them have cleared the infection spontaneously. Proof that some people can clear infection opens the door for research to discover how this works.
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| Prevention of Active Tuberculosis by Infection with Helicobacter pylori |
| | Jay Solnick, University of California at Davis, Davis, CA, United States - US |
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Jay Solnick of the University of California, Davis will explore whether the bacteria Helicobacter pylori, which can cause peptic ulcers in some people, might enhance immunity to tuberculosis and help maintain tuberculosis in a latent state. |
| Protection Against Latent TB Infection by the Cystic Fibrosis Mutation |
| | Jerry Nick, National Jewish Health, Denver, CO, United States - US |
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Because cystic fibrosis patients and carriers appear to be resistant to tuberculosis, Jerry Nick of National Jewish Medical and Research Center in the U.S. will study whether mutations of the CFTR gene, which causes the disease, reduce or eliminate latent TB infection. |
| Senescent and Rejuvenated Mtb Subsets on Exit from Latency |
| | Carl Nathan, Cornell University, New York, NY, United States - US |
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Carl Nathan and Gang Lin of Weill Cornell Medical College will test their hypothesis that tuberculosis is able to exit latency by distributing damaged proteins to a senescent cell lineage, while more functional proteins are diverted to a lineage with full replication potential. Regulating this post-latency cell division could be the target of novel drug therapies. |
| Targeted Capture of Latent M. Tuberculosis Cells From a Mammalian Host |
| | Kim Lewis, Northeastern University, Boston, MA, United States - US |
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In an attempt to capture and study latent tuberculosis cells, which are reservoirs of infection and highly resistant to treatment, Kim Lewis of Northeastern University will pulse-label tuberculosis cells with green fluorescent protein. While active cells divide and dilute the GFP, latent cells, which are dormant, will remain bright green, allowing for their observation and tracking. |