Showing Grants 1 to 10 of 45 |
| A New Platform for Making Effective Vaccines Against Pathogens That Cause Infectious Diseases |
| | Ellen Vitetta, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, United States - US |
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Ellen Vitetta of University of Texas Southwestern Medical Center at Dallas is developing a new vaccine platform that will utilize synthetic B cell epitope mimetics (peptoids) conjugated to protein carriers to make vaccines that will induce robust, specific, and protective antibody responses against pathogens. |
| Anaerobic Shock as a Novel Treatment for Tuberculosis |
| | Xilin Zhao, University of Medicine and Dentistry of New Jersey, Newark, NJ, United States - US |
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Xilin Zhao of the University of Medicine and Dentistry of New Jersey will test whether anaerobic gas, which causes rapid depletion of oxygen, will kill the tuberculosis bacteria without permanent damage to surrounding tissue. |
| Arctic Essential Genes Used to Create Temperature Sensitive Pathogens |
| | Francis Nano, University of Victoria, Victoria, B.C., Canada - CA |
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Francis Nano of Canada’s University of Victoria will introduce essential genes found in Arctic bacteria into the genomes of “warm-loving” pathogens, making them unable to grow at core body temperatures. Such microbes could survive on human skin, which is cold enough to allow for replication and the stimulation of a strong immune system response, but not survive further dissemination into deeper and warmer tissue. |
| Block Malarial Transmission by Targeting Gametocyte Activation |
| | Greg Garcia, Walter Reed Army Institute of Research, Silver Spring, MD, United States - US |
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To interrupt reproduction of the malaria parasite in the mosquito gut, Greg Garcia and Sheetij Dutta of Walter Reed Army Institute of Research seek to identify and block a gametocyte stage receptor for xanthreunic acid, which is known to trigger the differentiation of gametocytes, an essential step in the life-cycle of the malaria parasite. |
| Development of a Single Dose, Multicomponent, Thermostable Vaccine |
| | Yasmin Thanavala, Roswell Park Cancer Institute, Buffalo, NY, United States - US |
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Using thermostable nanoparticles as a delivery mechanism, Yasmin Thanavala of Health Research Inc and Roswell Park Cancer Institute in the U.S. will work to develop a single dose vaccine that can be given as close to birth as possible to protect against multiple diseases. |
| Development of a Type III Protein Secretion System as a Quasi-Synthetic Protein Antigen Delivery Nanomachine |
| | Jorge Galan, Yale University, New Haven, CT, United States - US |
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Type III protein secretion systems are used by many bacteria to inject proteins into mammalian cells. Jorge Galan of Yale University will develop an antigen delivery machine based on the type III protein delivery system that will not require the use of live-attenuated bacteria, offering a safer vaccine platform. |
| Development of Methods to Induce or Improve Immune Responses Directed Against Cryptic Microbial Antigens |
| | Hugo Soudeyns, Centre de recherche du CHU Sainte-Justine, Montreal, Quebec, Canada - CA |
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Hugo Soudeyns of Canada's Centre de Recherche du CHU Sainte-Justine will incorporate engineered frameshifting gene cassettes into vaccine vectors in hopes of eliciting broader T helper and cytotoxic T cell response, leading to better protection against disease. |
| DNA Vaccines with Strongly Enhanced Potency |
| | Andrew Heath, University of Sheffield, Sheffield, United Kingdom - GB |
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Andrew Heath of University of Sheffield in the U.K. will research whether the immune responses to DNA vaccines can be enhanced with novel adjuvants. |
| Efficacy of L-isoleucine Supplemented Food and Vitamin D in the Treatment of Childhood Pneumonia and Diarrhea in Hospitalized Patients: A Novel Therapeutic Approach |
| | Nur Alam, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh - BD |
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Nur Alam of the International Centre for Diarrhoeal Disease Research, Bangladesh will test whether adding L-isoleucine and Vitamin D to food served to hospitalized children will induce secretion of antimicrobial peptides that can aid recovery from acute diarrhea and pneumonia. |
| Endectocides for Controlling Transmission of Mosquito-borne Diseases |
| | Brian Foy, Colorado State University, Fort Collins, CO, United States - US |
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Brian Foy and Massamba Sylla of Colorado State University will research whether providing endectocides, drugs that kill parasitic worms, to animals and humans will effectively kill mosquitoes which feed on them. Through targeted and spaced drug administration, mosquitoes incubating disease-causing pathogens are expected to die prematurely, thus interrupting disease transmission, but these methods would limit the development of endectocide resistance. |