Showing Grants 1 to 10 of 26 |
| A Low-Cost, Rapid, and Sensitive Malaria Diagnostic Tool |
| | Sang-Yeon Cho, New Mexico State University, Las Cruces, NM, United States - US |
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Sang-Yeon Cho and Immo Hansen of New Mexico State University in the U.S. seeks to develop a malaria test that measures antibody-antigen reactions through a nanohole to indicate the presence of malaria parasites. |
| A Single-Step Device for Monitoring Mucosal Iga Titers |
| | Kevin Plaxco, University of California, Santa Barbara, CA, United States - US |
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Kevin Plaxco of the University of California, Santa Barbara, United States seeks to develop a diagnostics platform based upon measuring the electric current produced by the binding of antibodies to DNA molecules. If successful, this method will provide a rapid, single-step reagent free measurement of immune antibodies which could significantly augment disease detection and vaccine validation efforts. |
| Compact Disc Diagnostics for Early Disease Detection |
| | Robert Dunn, University of Kansas Center for Research, Inc, Lawrence, KS, United States - US |
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Robert Dunn and colleagues at the University of Kansas in the U.S. will develop a diagnostic tool for the early detection of disease that employs writable compact discs that can be read in conventional computer disc drives. Microfluidic structures and immobilized antibodies will be fabricated onto small sections of a compact disc, along with enzymes that produce a reflective “silvering” surface upon recognition of target biomarkers. These changes in reflection can be read by any conventional CD drive, allowing for diagnosis using laptops in low resource settings. |
| Cost-Effective Testing of Blood Samples Using Cellphones |
| | Aydogan Ozcan, University of California, Los Angeles, CA, United States - US |
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Aydogan Ozcan of the University of California, Los Angeles in the U.S. will test the feasibility of a lens-free cell phone microscope for rapid, automated and accurate diagnosis of malaria in field settings. This on-chip cell phone microscope is based on digital holography and does not require any lenses, lasers or other bulky components making it extremely cost-effective and compact. |
| Detecting Pathogenic Microbes by a “Microbial Litmus Strip” |
| | Liaohai Chen, Rush University Medical Center, Chicago, IL, United States - US |
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Liaohai Chen of Rush University Medical Center in the U.S. will develop nanoparticles which react to the presence of pathogenic microbes by releasing encapsulated substances that quickly amplify the binding signals. These nanoparticles can be placed on the tip of a litmus strip as a colorimetric assay to indicate the presence and concentration of pathogens. |
| Exhaled Diagnosis of MTb |
| | Simon Spivack, Albert Einstein College of Medicine, Bronx, NY, United States - US |
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Simon Spivack, Albert Einstein College of Medicine in the U.S. will test the theory that DNA of the Tuberculosis bacterium can be detected in exhaled breath. The team will capture exhaled breath condensate samples via a non-invasive device and use nucleic acid amplification to detect the presence of mycobacteria. |
| G-Protein Coupled Receptors to Detection Infectious Agents |
| | Ethan Lerner, Massachusetts General Hospital, Boston, MA, United States - US |
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Ethan Lerner of Massachusetts General Hospital in the U.S. will attempt to reverse engineer in vitro G-protein coupled receptors (GPCRs), which usually are used by the human body to sense light, odors, tastes and hormones, to detect selected parasite biomarkers. If successful, these engineered receptors could be used to develop a diagnostic sensor for infectious agents. |
| Hand-Held Proteomic NanoLab for Infectious Diseases |
| | Shan Wang, Stanford University, Stanford, CA, United States - US |
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Shan Wang of Stanford University in the U.S. will refine a prototype diagnostic platform which uses GMR sensors, commonly used in hard disk drives, to detect proteins labeled with magnetic nanoparticles. By employing GMR sensors on disposable “NanoLab” sticks, Wang and his team hope to produce an easy to use, ultraportable diagnostic device for rapid point-of-care HIV screening in the developing world. |
| Instrument-Free Detection of DNA Disease Markers |
| | Vyas Sharma, University of North Carolina, Chapel Hill, NC, United States - US |
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Vyas Sharma and David Lawrence of the University of North Carolina, Chapel Hill in the U.S. will develop a diagnostic platform based on seed germination by integrating DNA amplification with the expression of reporter proteins in plant seeds to aid in the detection of infectious diseases. |
| Low-Cost, Rapid, Multiplexed Detection of TB |
| | Vineet Gupta, University of Miami, Miami, FL, United States - US |
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Vineet Gupta of the University of Miami in the U.S. will develop a computational model to identify new DNA sequences in the Tuberculosis bacterium that can be used as biomarkers, and then employ zinc-finger tags to detect the identified DNA sequence in a diagnostic test. |